![]() ![]() ![]() We report a case of transverse myelitis after COVID-19 vaccination. In addition, only oral polio vaccine was found to have a pathogenic causal relationship while other vaccines showed a temporal relationship to TM due to a common denominator such as an adjuvant. However, some studies have reported its occurrence following administration of other vaccines, including diphtheria, tetanus toxoids and pertussis vaccine, measles, mumps, and rubella (MMR) virus vaccine, oral poliovirus vaccine, Japanese encephalitis virus vaccine, hepatitis B vaccine, yellow fever vaccine, typhoid vaccine, rabies vaccine, and seasonal influenza virus vaccine. Transverse myelitis (TM) is a very uncommon condition, and rarer is the vaccine-associated TM. Considering the large-scale vaccination campaign and less prevalence of neurological conditions in the population, the post-vaccination neurological morbidity may be due to chance alone. However, due to the passive surveillance, the VAERS database is subjected to reporting bias and may contain some errors. ![]() Īccording to the analysis of the database by CDC in the first month of vaccination, there appear to be very little to no safety concerns along with respect to the causal link between these side effects and vaccination. Other serious neurological manifestation such as stroke, Guillain-Barré syndrome, Bell’s palsy, transverse myelitis and acute disseminated encephalomyelitis were also reported in the VAERS database and Medicines and Healthcare products Regulatory Agency (MHRA) from UK, COVID-19 database. On some rare occasions, tremor, dysphonia, diplopia, tinnitus, seizures and reactivation of herpes zoster have been reported. The predominant post-vaccination side effects are the nonspecific systemic symptoms, among which the neurological symptoms include dizziness, headache, pain, muscle spasms, myalgia and paresthesia. The Vaccine Adverse Event Reporting System (VAERS) of Centers for Disease Control (CDC) has reported AEFI related to Pfizer-BioNtech, Moderna and Johnson and Johnson’s COVID-19 vaccines, among which there are reported neurological complications ranging from facial palsy to stroke. As the coronavirus (COVID-19) vaccines are being distributed around the world, we are witnessing the rise of Adverse Event following Immunization (AEFI). ![]()
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